2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168817
    Δ9-Tetrahydrocannabiorcol
    Δ9-Tetrahydrocannabiorcol is structurally similar to known phytocannabinoids.
    Δ9-Tetrahydrocannabiorcol
  • HY-170733
    Cannabidiol monomethyl ether
    Cannabidiol monomethyl ether is a phytocannabinoid.
    Cannabidiol monomethyl ether
  • HY-168813
    Δ9-THCH
    Δ9-THCH is structurally similar to known phytocannabinoids.
    Δ9-THCH
  • HY-13505R
    AM281 (Standard)
    		Antagonist
    AM281 (Standard) is the analytical standard of AM281. This product is intended for research and analytical applications. AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM.
    AM281 (Standard)
  • HY-170726
    (±)-CBCP
    (±)-CBCP ((±)-Cannabichromephorol) is structurally similar to known phytocannabinoids.
    (±)-CBCP
  • HY-W775308
    Cannabicyclolic acid
    Cannabicyclolic acid is a certified reference material categorized as a photodegradation product of the phytocannabinoid Cannabichromenic acid.
    Cannabicyclolic acid
  • HY-170700
    CHM-FUBIATA
    CHM-FUBIATA is structurally similar to known synthetic cannabinoids.
    CHM-FUBIATA
  • HY-172056
    PB-22 N-Pentanoic acid-3-carboxyindole metabolite
    PB-22 N-Pentanoic acid-3-carboxyindole metabolite is a metabolite of PB-22. PB-22 is a cannabinoid.
    PB-22 N-Pentanoic acid-3-carboxyindole metabolite
  • HY-135280
    MRL-650
    		Inhibitor
    MRL-650 (CB1 inverse agonist 1), a chemical probe, is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.
    MRL-650
  • HY-170044
    iso-Hexahydrocannabinol
    iso-Hexahydrocannabinol is structurally similar to known phytocannabinoids.
    iso-Hexahydrocannabinol
  • HY-14753
    Rosonabant
    		Antagonist
    Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder.
    Rosonabant
  • HY-114826S
    Prostaglandin E2-1-glyceryl ester-d5
    		Activator
    Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceyl ester-d5) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
    Prostaglandin E2-1-glyceryl ester-d<sub>5</sub>
  • HY-168819
    Δ8-iso-THC
    Δ8-iso-THC is structurally similar to known phytocannabinoids.
    Δ8-iso-THC
  • HY-N1415S1
    β-Caryophyllene-13C,d2
    		Agonist
    β-Caryophyllene-13C,d2 is 13C and deuterated labeled β-Caryophyllene (HY-N1415). β-Caryophyllene is a CB2 receptor agonist.
    β-Caryophyllene-<sup>13</sup>C,d<sub>2</sub>
  • HY-129304
    (±)-Cannabichromeorcin
    (±)-Cannabichromeorcin is a cannabinoid.
    (±)-Cannabichromeorcin
  • HY-139240
    Cannabidihexol
    Cannabidihexol is a phytocannabinoid with analgesic activity in mice.
    Cannabidihexol
  • HY-172063
    3-CAF
    3-CAF is a synthetic cannabinoid featuring a 3-carboxylate-indazole structure.
    3-CAF
  • HY-116714
    Cannabigerorcinic acid
    Cannabigerorcinic acid is structurally similar to known phytocannabinoids.
    Cannabigerorcinic acid
  • HY-171025
    Cannabiorcol
    Cannabiorcol (Cannabinol C1) is structurally similar to known phytocannabinoids.
    Cannabiorcol
  • HY-170722
    Cannabigerolic acid monomethyl ether
    Cannabigerolic acid monomethyl ether is structurally similar to known phytocannabinoids.
    Cannabigerolic acid monomethyl ether
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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