2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Related Products

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14753
    Rosonabant
    		Antagonist
    Rosonabant is a selective antagonist for cannabinoid receptor (CB1 receptor), which reduces body weight and improves improves the risk of obesity-related cardiovascular metabolic diseases. Rosonabant exhibits adverse side effect, such as nausea and mental disorder.
    Rosonabant
  • HY-114826S
    Prostaglandin E2-1-glyceryl ester-d5
    		Activator
    Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceyl ester-d5) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
    Prostaglandin E2-1-glyceryl ester-d<sub>5</sub>
  • HY-168819
    Δ8-iso-THC
    Δ8-iso-THC is structurally similar to known phytocannabinoids.
    Δ8-iso-THC
  • HY-N1415S1
    β-Caryophyllene-13C,d2
    		Agonist
    β-Caryophyllene-13C,d2 is 13C and deuterated labeled β-Caryophyllene (HY-N1415). β-Caryophyllene is a CB2 receptor agonist.
    β-Caryophyllene-<sup>13</sup>C,d<sub>2</sub>
  • HY-129304
    (±)-Cannabichromeorcin
    (±)-Cannabichromeorcin is a cannabinoid.
    (±)-Cannabichromeorcin
  • HY-139240
    Cannabidihexol
    Cannabidihexol is a phytocannabinoid with analgesic activity in mice.
    Cannabidihexol
  • HY-172063
    3-CAF
    3-CAF is a synthetic cannabinoid featuring a 3-carboxylate-indazole structure.
    3-CAF
  • HY-116714
    Cannabigerorcinic acid
    Cannabigerorcinic acid is structurally similar to known phytocannabinoids.
    Cannabigerorcinic acid
  • HY-171025
    Cannabiorcol
    Cannabiorcol (Cannabinol C1) is structurally similar to known phytocannabinoids.
    Cannabiorcol
  • HY-170722
    Cannabigerolic acid monomethyl ether
    Cannabigerolic acid monomethyl ether is structurally similar to known phytocannabinoids.
    Cannabigerolic acid monomethyl ether
  • HY-110065
    SER-601
    		Agonist
    SER-601 is a potent and selective peripheral cannabinoid (CB2) receptor agonist with a Ki of 6.3 nM. SER-601 has analgesic and antidiabetic properties and can be used for relevant research.
    SER-601
  • HY-W345492
    Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate
    Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate (1-(Cyclohexylmethyl)-1H-indole-3-carboxylic Acid Methyl Ester) is an analog of BB-22 that lacks the quinoline group. BB-22 is an analog of cannabinoid.
    Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate
  • HY-172035
    5-Fluoro PB-22 5-hydroxyquinoline isomer
    5-Fluoro PB-22 5-hydroxyquinoline isomer is a synthetic cannabinoid.
    5-Fluoro PB-22 5-hydroxyquinoline isomer
  • HY-172058
    5-Fluoro THJ
    5-Fluoro THJ is a derivative of THJ-018. THJ-018 is a synthetic cannabinoid.
    5-Fluoro THJ
  • HY-168369
    Anti-inflammatory agent 94
    		Ligand
    Anti-inflammatory agent 94 (compound 4b) is a potent cannabinoid ligand with Kis of 29 nM and 8 nM against CB2 and CB1. Anti-inflammatory agent 94 can be utilized in inflammation rersearch.
    Anti-inflammatory agent 94
  • HY-170477
    Δ8-THCP
    Δ8-THCP (Δ8-Tetrahydrocannabiphorol; n-Heptyl Δ8-THC) (Compound 1a) is a semisynthetic cannabinoid that serves as an analytical reference standard and exhibits affinity for the CB1 receptor.
    Δ8-THCP
  • HY-158857
    ortho-CBNQ
    ortho-CBNQ (o-Cannabinolquinone) is an oxidative byproduct of Cannabidiol.
    ortho-CBNQ
  • HY-171040
    Δ4-Iso-THC
    Δ4-Iso-THC (Δ4-Iso-tetrahydrocannabinol) is a cannabidiol derivative with potential cytotoxicity targeting cancer cells.
    Δ4-Iso-THC
  • HY-123410
    KM-233
    KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research.
    KM-233
  • HY-U00397
    CB1 antagonist 1
    		Antagonist
    CB1 antagonist 1 is an antagonist of CB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions.
    CB1 antagonist 1
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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